Yazar "Görmüş, Uzay" için listeleme
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11β HSD-1 and PAI-1 gene expression fructose induced metabolic syndrome rats
Akan, Gökçe; İnan, Öznur; Atalar, Fatmahan; Görmüş, Uzay; Bilir, Ayhan; Özdilli, Kürşat; Altuğ, Tuncay (2013)Backround: Metabolic syndrome (MetS) is an important health issue worldwide. It is a prevalent and complex disease, characterized by the variable coexistence of obesity, dyslipidemia, hyperinsulinaemia, and hypertension. ... -
25-Hydroxyvitamin D levels are related to hyperinsulinemia in polycystic ovary syndrome
Güdücü, Nilgün; Görmüş, Uzay; Kutay, Salih Serdar; Kavak, Zehra Neşe; Dünder, İlkkan (Informahealthcare, 2014)Aim: To determine 25-hydroxyvitamin D levels and the relationship between 25-hydroxyvitamin D and metabolic disturbances including insulin resistance in women with PCOS. Materials and methods: We compared biochemical, ... -
The association between coronary atherosclerotic burden and asymmetric dimethylarginine, carotis intima media thickness and endothelial function.
Can, Fatma; Ziyrek, Murat; Erdem, Şükran; Civan, Murat; Görmüş, Uzay; Şahin, Sinan; Çiftçi, Çavlan (Türk Kardiyoloji Derneği, 2014)Objectives: Detection of extent and severity of atherosclerosis using easy, non-invasive methods is of great importance. Atherosclerotic burden may be evaluated with the Gensini scoring system (GSS). Carotis intima media ... -
Comparison of chemiluminescence microparticle ımmunoassay and electrochemiluminescence ımmunoassay for detection of HBsAg
İnan, Neşe; Demirel, Aslıhan; Kabakoğlu Ünsur, Emel; Görmüş, Uzay; Sönmez, Emine; Tabak, Fehmi; Arısoy, Ayşe (Galenos Yayınevi, 2014)Objectives: Hepatitis B virus (HBV) infection is a major global public health problem. Determination of serum markers is crucial for rapid screening and clinical diagnosis of HBV infection. The detection of hepatitis B ... -
Cox-2 gene polymorphism and IL-6 levels in coronary artery disease
Ol, K.K.; Ağaçhan, Bedia; Görmüş, Uzay; Toptaş, Bahar; İsbir, Turgay (Funpec-Editora, 2011)Coronary artery disease is one of the leading causes of mortality and diabetes mellitus is one of its main risk factors due to microvascular and macrovascular complications, such as atherosclerosis. Atherosclerosis is now ... -
Diabetik retinopatili hastaların vitreus örneklerinde IL-8 ve TNF-A seviyeleri
Rasier, Rıfat; Artunay, Özgür; Yüzbaşıoğlu, Erdal; Şengül, Alper; Görmüş, Uzay; Öncel, Murat; Bahçecioğlu, Halil (Gazi Göz Vakfı, 2011)Amaç: Diyabetik retinopati (DR) Diyabetes mellitus (DM) hastalarında sıkça rastlanan, görme keskinliğinde ani ve ciddi kayıplara yol açan mikrovasküler bir komplikasyondur. Bu çalışmadaki amacımız DR nedeniyle pars plana ... -
DNA repair based therapy in oncology and neurodegeneration
İsbir, Turgay; Görmüş, Uzay; Timirci-Kahraman, Özlem; Ergen, Arzu; Dalan, Altay Burak; Güleç-Yılmaz, Seda; Atasoy, Hande (InTech, 2015)This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of ... -
DNA repair, cancer and cancer therapy- the current state of art
İsbir, Turgay; Demircan, Berna; Kıraç, Deniz; Dalan, Burak; Görmüş, Uzay (InTech, 2011)Over the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research ... -
Effect of coffee extracts on intracellular calcium level in levels in glial cells
Akın, Demet; Görmüş, Uzay; Yapışlar, Hande; Farah, Adriana (ASIC 2012 International Conference - Costa Rica, 2012)Widely used antidepressant drugs such as fluoxetine exert additional blocking effects on voltage gated Ca⁺² channels. Differences in intracellular calcium levels may be involved in the release of monoamines, which play ... -
Effect of obesity and serum leptin level on clopidogrel resistance
Doğan, Ali; Kahraman, Serkan; Usta, Emrah; Özdemir, Emrah; Görmüş, Uzay; Çiftçi, Çavlan (Türk Kardiyoloji Derneği, 2016)Objective: Clopidogrel inhibits platelet aggregation by blockade of platelet adenosine diphosphate (ADP) P2Y12 receptor. Leptin is the obesity gene product, and its serum level increases with obesity. Platelets have leptin ... -
Embriyogenez ve karsinogenez ilişkisi.
Görmüş, Uzay (2011)Embriyogenez ve kanser oluşumu mekanizmaları arasında birçok moleküler ilişki söz konusudur. Embriyogenezde kontrollü hücre bölünmesi, farklılaşması, göçü ve programlanmış hücre ölümü olayları izlenmektedir. Embriyonik ... -
Endogenous sex hormones and their associations with cardiovascular risk factors in post-menopausal women
Güdücü, Nilgün; Görmüş, Uzay; Kutay, Salih Serdar; Kavak, Zehra Neşe; Telatar, Berrin (Springer Link, 2013)Aims: Our aim was to understand the relationship between endogenous sex hormones and cardiovascular disease (CVD) risk factors in post-menopausal women. Materials and methods: Eighty-three post-menopausal women from a ... -
Expression levels of elastin and related genes in human varicose veins
Görmüş, Uzay; Timirci-Kahraman, Özlem; Ergen, Arzu; Kunt, A. T.; İsbir, Selim; Dalan, A. Burak; İsbir, Turgay (2014)Among the suspected reasons for varicose vein formation are changes in the quantity and content of the elastin protein; however, comprehensive investigations about elastin assembly in varicose vein formation are yet ... -
Fas-1377 A/G polymorphism in lung cancer
Görmüş, Uzay; Ergen, Arzu; Yaylım-Eraltan, İlhan; Yılmaz, Hülya; Turna, Akif; Bozkurt, Nilüfer; İsbir, Turgay (International Institute of Anticancer Research, 2007)Background: Reduced expression of Fas and/or increased expression of FasL is known to exist in some cancer types including lung cancer, so the Fas/FasL system may play a role in the course of cancer. Lack of cell surface ... -
Fas-1377A/G and fasL-844 T/C gene polymorphisms and epithelial ovarian cancer
Görmüş, Uzay; Ergen, Arzu; Yılmaz, Hülya; Dalan, Burak; Berkman, Sinan; İsbir, Turgay (International Institute of Anticancer Research, 2007)BACKGROUND: The Fas receptor is known to be widely expressed in various tissues and FasL is highly expressed on cells of the immune system and also on cells of immune-privileged areas such as the eyes and brain. Ovarian ... -
Galaktoz, fruktoz ve pentoz metabolizması
Görmüş, Uzay (Nobel Tıp Kitabevi, 2017)Bu bölümde glukoz dışındaki diğer heksozların ve pentozların metabolizması ele alındı. -
Leptin and leptin receptor polymorphisms are related to body mass index in a Turkish population
Görmüş, Uzay; Timirci-Kahraman, Özlem; Toptaş, Bahar; İsbir, Turgay; Çiftçi, Çavlan; Berkkan, Hasan Hakan; Karatay, Mutia Canan (TUBİTAK, 2014)Background/aim: Leptin is a hormone that is known to be related to weight gain and obesity. The soluble leptin receptor has been found in plasma as an important determinant of leptin sensitivity. In this study, our goal ... -
Mean platelet volume in gestational diabetes mellitus
Güdücü, Nilgün; Sidar, Güliz; Görmüş, Uzay; İşci, Herman; Başgül Yiğiter, Alin; Dünder, İlkkan (İstanbul Bilim Üniversitesi, Tıp Fakültesi, 2015)Objectives: This study aims to compare mean platelet volume of pregnants with gestational diabetes mellitus to a healthy control group and to detect the relationship between mean platelet volume and fasting blood ... -
Metabolizma atlası. Bir bakışta metabolizma
Salway, J.G. (İstanbul tıp kitabevi, 2012)Bir bakışta metabolizma, metabolizmanın sağlık ve hastalık durumlarındaki hallerini farklı bir bakış açısıyla değerlendirmektedir. Farklı mekanizmalar anlatılsa da kitap boyunca metabolizmanın bütün olarak ele alınmasına ... -
MMP2 gene polymorphisms and MMP2 mRNA levels in patients with superficial varices of lower extremities
Görmüş, Uzay; Timirci Kahraman, Özlem; İsbir, Selim; Tekeli, Atike; İsbir, Turgay (The International Institute of Anticancer Research, 2011)Background: Although superficial varices of the lower extremities are common and with high morbidity, their etiology has not been elucidated yet. Previously, it was thought that venous hypertension was responsible for such ...